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She fractured her jaw during eating, all rip attachments to the vertebral columns are broken, legs broken. Bone Metastases. Reddit; Wechat; Abstract. Not only for myself, but for the people who have to watch, like I did. As well as being in his lymph nodes and bladder. The opposite is most painful. I don't know your diagnosis, prognosis, or current health status. radiation and death are the way around the pain. Reddit; Wechat; Bone is a preferred site for metastases owing to local signals that promote skeletal colonization. Edit: Due to common repeated questions. The sites of bone metastases were the vertebrae (15/19, 79%), pelvis (3/19, 16%), ribs (3/19, 16%) and femur (2/19, 11%). found bone metastases in 27 per cent of autopsied patients with carcinomas. One day we had to attend an hour on the autopsy table where we had a guy with metastatic bone cancer that OD-ed with morphine (maybe even euthanised by a doctor or nurse). We report a case of bone metastases from bronchogenic carcinoma in a patient with TS bone changes. Background: Currently bisphosphonates are often administered to patients with osteolytic bone metastases from several neoplasms. Whereas an increasing body of mechanistic studies expanded our understanding on bone tropism, they also revealed complexity across the bone lesions originated from different cancer types. • Posted by u/[deleted] 2 months ago. Apparently he was in so much pain that he scratched any surface he could find and bite himself to at least relieve himself from the agonizing pain. Your doctor may do lab tests and imaging tests (like x-rays or bone scans) to see if and/or how far the cancer has spread. Reddit; Wechat; SUMMARY. I still think about her 20 years later. When I was in medical high school we had to practise at the Oncology department. Fuck cancer. Close. Bone metastases can be classified as lytic, blastic, or mixed depending on the activity of tumor-stimulated host osteoclasts and osteoblasts. Bone‐targeted agents can reduce the risk of SREs. They almost missed the fractures because of the cancer, and I know that eventually he’ll break something somewhere they can’t find or treat. Prostate cancer bone metastases - 6 months after first meta. r/Radiology. That is not a joke or embellishment. It’s cruel and horrific. 77. Press question mark to learn the rest of the keyboard shortcuts. Crossposted by 2 months ago. Other autopsy studies report bone me- tastases in 47 to 85 per cent of women dying from breast cancer, in 33 to 85 per cent of patients with prostatic cancer, and in 32 to 60 per cent of patients with lung cancer (86). I was a few rooms down from a bone cancer patient once, after having my appendix removed. He recently fractured his femur from walking, but the surgeon managed to put a bolt through it and treat it with radiation, so he’s doing alright. It has now spread to her brain via nervous system and is pressing on the frontal lobe. Objective. However, the risk factors for SREs during BMA treatment are not well‐understood. 6.1k points. Things that make you say "What the F*ck". People i work with shine like Christmas trees. Pain medicine cannot reach the pain. occur when cancer cells break off from a primary tumor that is somewhere else in the body I'm with you: Kill me. Introduction In solid tumours, bone metastasis most commonly happen in prostate, breast and lung cancers. Google PET scan bone mets. A consecutive series of 95 patients with hypernephroma was studied retrospectively after it was clinically suspected that there was a propensity for this tumor to metastasize to the scapula. Bone metastases in patients with solid tumours (ST) and bone lesions in patients with haematological malignancies (HM) are common. Is amputation a valid choice or does it spread quickly? This makes it a lot scarier. INVESTIGATIONS ON the pathogenesis of cancer metastasis to bone have received increased attention by scientists worldwide. This study evaluated the number and timing of SREs from case studies to identify these factors. We call them frequent fliers because they'll be back and not that many times before their primary cancer wins its battle. It was horrible to watch her die slowly from it cuz you just wanted her to die fast so she didn’t have to suffer. The body does an amazing job keeping a constant stream of various cancerous cells at bay. That’s terrifying. I am with you. 1, 2 As metastases occur, the normally tempered osteoclasts are transformed into unruly bullies, proliferating and resorbing bone with abandon. New comments cannot be posted and votes cannot be cast, More posts from the interestingasfuck community, Press J to jump to the feed. Associated skeletal‐related events (SREs) cause severe pain, reduced quality of life and place a burden on health care resources. This is why there will never be a general cure for cancer, only particular cancers. Not into the bones. Bone‐modifying agents (BMAs) reduce the incidence of skeletal‐related events (SREs) and are thus recommended for breast cancer patients with bone metastases. Metastases preferentially target the lymph nodes, lung, liver, or bone. Her last week has begun, the pain is extremely crazy and she is full on morphium if that even helps. She is losing her mind, voice and ability to speak/understand. In vertebra spine, bone metastasis can cause catastrophic compression fracture (bone fracture that compresses the spinal cord) which leads to: paraplegia (paralysis of both lower legs) quadriplegia (paralysis of both upper and lower limbs if compression fracture happened at higher… My grandpa died of the bone cancer you're talking about. Reddit; Wechat; Abstract. Bone metastases in patients with metastatic renal cell carcinoma (mRCC) do not independently affect oncologic outcomes or survival, according to data presented at SUO 2020, a … Reddit; Wechat; Abstract. Amputation isn't an option at this point because treatment is simply palliative and for pain management, not cure. u/thellios. Bone metastases are sometimes found because they cause problems, but in some cases, they’re found before you have any symptoms. He was fourth stage when he was diagnosed. log in sign up. Reddit; Wechat; Abstract en. 16. Reddit; Wechat; Abstract. He even had some damaged tendons from flexing his muscles so much because of the pain. This means the cancer has spread from other parts of the body or stage 4 cancer. A variety of palliative treatment modalities is available for bone metastases ranging from local to systemic, and from non‐invasive to invasive. Metastasis to bone from carcinoma of the thyroid was noted in 33 (12.7%) of 259 patients referred to the Nuclear Medicine Section of the University of California Medical Center, San Francisco from 1945 through 1964. Bone scintigraphy and magnetic resonance imaging are useful in distinguishing the TS bone lesions from bone metastases. The clinical records, scintigrams, radiographic skeletal surveys, and bone marrow aspiration and trephine results of 30 children with neuroblastoma were reviewed to determine the relationship between the result of the scintigram and the clinical outcome of the patient. September 13, 2019. Bone metastases were mainly localized to the spine (61%), pelvic bones (15%), ribs (8%) or other sites (16%), without significant differences between the NPC and the non-NPC patients. Bone metastases develop in approximately 30% to 40% of people with advanced NSCLC, with metastases either present at the time of diagnosis or developing during the course of the neoplastic disease. Press J to jump to the feed. Along with the other things I saw at the hospital, it still gives me nightmares. When literally a hole is punched in the bone. The pain is unending even when using extremely high doses of every narcotic in my arsenal. Abstract Although bone marrow examination is a common procedure in the evaluation of patients with cancer, its role and contribution have been questioned in recent years. Just curios, because everybody in my family, up to6 generations before are died from some kind of cancer and one of them was a bone cancer. Close. Before you read what I write, I have no clue about cancer treatment and etc. Cookies help us deliver our Services. He was the toughest, strongest man I've ever known and by the time he passed away he was a thin withered husk. I’m so sorry for your loss. New comments cannot be posted and votes cannot be cast. I hope I never meet any of you or your families. Sclerotic and lytic bone changes of tuberous sclerosis (TS) can mimic bone metastases. I'm also not a doctor, just a licensed radiation therapist in the midwest. User account menu. Yes, my 42 year old brother had the "opposite", multiple myeloma. My best mate died of it in 1988. Abstract Purpose: To evaluate whether enhancement on serial dynamic gadolinium‐enhanced abdominal–pelvic MR imaging (DCE‐MRI) can determine the acuity of bone metastases… X-rays showed holes throughout his bones. He's been on keytruda for a while now and has been in a stable condition for the past months which I'm very thankful for . Doctors and nurses are saints for witnessing such things and they deserve at least another 0 in their paycheck. Posted by. If you have cancer now, please don't ask me questions, please ask your oncologist. Unlike hematological malignancies that originate in the blood and form non-solid tumors, bone metastases generally arise from epithelial tumors and form a … Press question mark to learn the rest of the keyboard shortcuts. Is the contrast media responsible for the coloration? Malignancy (defined as metastatic disease) has been reported in nearly 5% of head and neck paragangliomas. Skeletal-related events and pattern of care. Reddit; Wechat; Abstract. I know for sure I will deliberately inject a fatal dose of heroin/fentanyl if ever I end up in his situation. Only radiation and death are the way around the pain. Most of the patients received radiotherapy, chemotherapy or both, but 25 patients (33.3%) received palliative care only. People often regard cancer as a single disease when it's an entire category. bone metastases) are common and result in significant morbidity in patients with metastatic disease.Although the diagnosis is often straightforward, especially as in many cases there is a well-documented history of metastatic malignancy, sometimes they may mimic benign disease or other primary malignancies. That is a kind of bone cancer. I discussed my dad’s case in this thread. It’s the f’kin worst. Bone metastases are a common clinical problem that is associated with the potential for significant symptoms such as pain, pathologic fracture, spinal cord compression, and hypercalcemia. To determine the characteristics of patients with germ cell cancer and bone metastases. His fingernails were missing and there were bite marks everywhere on his body. Based on favorable experience in other cancers with bone metastases and the lack of effective treatment, we started to use zoledronic acid (ZA), a recently developed synthetic bisphosphonate drug, in the treatment of this disease. 302 comments. Patients and Methods . My aunts cancer moved to her bones and if you just laid a finger on her she would scream from the pain. My dad has lung cancer with several metastases (lung and lower spine mainly). 16. A look that implored me to help - yet there was no help I could offer. I’m an RN who has worked in hospice and has had a lot of bone cancer patients - moving them is horrific. What do you do? Bone is a frequent site of metastases in many cancers. Hopefully they were able to make him comfortable. My dad was diagnosed with prostate cancer that’s metastasised to the bone last year. This is the most common type of bone cancer because primary are much more rare. By using our Services or clicking I agree, you agree to our use of cookies. I treat bone cancer patients daily (radiation therapist), I'm not joking when I tell you I'm killing myself if I ever get a metastatic bone cancer diagnosis. I always thought radiation was basically destroying all cells in the cancerous area in hopes to also destroy the cancer. Reddit; Wechat; Summary. You could tell it was involuntary, and that she was consumed with misery. Palliative radiotherapy has proven to be successful in treating pain caused by metastatic lesions in any bone, and in treating neurological complaints caused by compression of the spinal cord due to lesions in the spinal column. Background. Methods. He’s only 65. I never said it in my original post, but cancer fucking sucks y'all. We know it’s a matter of time before something else fractures. My dad just died from this. The mom of my gf is going through exactly what you mentioned right now. There were bone metastases at diagnosis (0.51%, 13/2550) or at relapse (0.24%, 6/2550). Oh wow. Reddit; Wechat; Abstract. The clinical treatment of bone metastasis from breast cancer is currently based on the systemic administration of antiresorptive agents, radiopharmaceuticals, and/or local treatments such as radiation therapy, radiofrequency ablation and surgery. Bone metastases, or osseous metastatic disease, is a category of cancer metastases that results from primary tumor invasion to bone.Bone-originating primary tumors such as osteosarcoma, chondrosarcoma, and Ewing's sarcoma are rare. Skeletal metastases (a.k.a. This is one of those things. Cookies help us deliver our Services. Likely better than our best science if we were to be honest. Extensive bone cancer metastases!! It wasn't a whiny, complaining type of moaning. Ten patients (53%) had solitary, and nine patients (47%) had multiple, sites of bone metastases. It’s a profound moment to realise you want quality over quantity with someone you love. I’ve had patients with this diagnosis but... thought of it as like, tumors growing on the bones? A blessing really. This means the cancer has spread from other parts of the body or stage 4 cancer. I've never felt more sorry for a person in my life. Extensive bone cancer metastases!! Extensive bone cancer metastases!! Les métastases osseuses peuvent causer une morbidité importante, notamment de la douleur, des difficultés ambulatoires et une indépendance fonctionnelle réduite. She moaned in agony constantly. Somehow that makes it worse. This is the most common type of bone cancer because primary are much more rare. Reddit; Wechat; INTRODUCTION. The research team concluded that the B6Ca P line overcomes two critical limitations to study the skeletal metastasis of prostate cancer: PCa can now be studied in fully immunocompetent hosts and the injection produces bone metastases for scientists to study. Google PET scan bone mets. People i work with shine like Christmas trees. Hypercalcemia was the most frequently observed SRE in the non-NPC patients … Bone metastases have the potential to cause significant morbidity including pain, impairment of ambulation and reduced functional independence. The case records of patients with known germ cell tumours (GCTs) within the Anglian Germ Cell Cancer Group database between January 2005 and March 2011 were reviewed retrospectively. Pinterest Reddit Tumblr Digg More. I remember vividly the look on his face, the last time I went to see him. Press question mark to learn the rest of the keyboard shortcuts. This shit is the most cruel thing I have ever witnessed and it tears a lovely family apart. We describe three patients with multiple silent bone metastases exhibiting a fatty halo at MRI that coexisted with expansive bone lesions. It was horrible, and if it ever happens to me I'm with you, I'd rather take a bullet in the brain than go through what he did. When he was first diagnosed we were so concerned with how much time we had with him, now I don’t really care so long as he’s not in pain. The treatment of bone metastases comprises a large part of the radiotherapy daily practice. SREs occurred in 34 (27%) non-NPC patients and in 6 (9%) NPC patients, respectively . 12 Osteoclasts are large, multinucleated cells with a specialized cell membrane (the “ruffled border”) that resorb bone, and osteoblasts are smaller, mononucleated cells that form new bone. consensual internet hug. These tests may show bone metastases. Bone metastases were found in the spine (46.7%) and pelvis (42.7%). I know he’s my dad, but he’s such a lovely man, so reserved and kind, a true gentleman. The findings were published in … Imaging of bone metastases may rely on nuclear medicine [bone scintigraphy or singlephoton emission computed tomography (SPECT), positron emission tomography (PET), PET-CT, or SPECT-CT], on radiograph-based technologies (radiographs and CT), and on MRI. We were eight at the time. The cancer is in his spine, ribs, pelvis and thigh. As reported above, bone metastases are most frequently located in the axial skeleton, where an overlay of structures hampers the detection of decent findings when using XR, but detection of skeletal metastases in extremities is a valid method as no overlap of other structures or bones is present . Bisphosphonates were given as palliative therapy to 25 patients (33.3%). Forty‐three patients (57.3%) also had extra‐osseous metastases. Dr. Kenyon Meadows here, board-certified radiation oncologist with Southeast Georgia Health System Cancer Care Centers, and today’s video blog topic is bone metastases. Both bone properties and the tumor-intrinsic traits are associated with the metastatic propensity to bone (i.e., the bone tropism). The pain he was in looked unbelievable. Sorry to hear it. This makes me so worried. r/Radiology: We aim to become the reddit home of radiologists, radiographers, technologists, sonographers and lay-users interested in medical … Press J to jump to the feed. Amputation isn't an option at this point because treatment is simply palliative and for pain management, not cure. , so is there any way to completely cure a cancer in a stage when rapid cell mutation already started?Also example of a opposite kind of bone cancer, this is a slow process, not like a just hole suddenly appeared in a bone? There is so much worse than death. All of his known metastases have shrunken significantly since then (part of his lungs was removed aswell). I'm specifically talking about bone metastasis. He lasted only three months from diagnoses. Toxic chemo did him in, as he suffered a heart attack. As someone with no knowledge on radiation or how it works, could you elaborate on how radiation helps with the pain? By using our Services or clicking I agree, you agree to our use of cookies. Citing Literature. The cancer is in his spine, ribs, pelvis and thigh moved to her brain via nervous and. In this thread parts of the keyboard shortcuts from flexing his muscles so much because the! Please do n't know your diagnosis, prognosis, or bone most common type of moaning coexisted with expansive lesions! Works, could you elaborate on how radiation helps with the pain write. Given as palliative therapy to 25 patients ( 47 % ) radiation therapist in the cancerous in. Autopsied patients with multiple silent bone metastases have the potential to cause significant including. Choice or does it spread quickly, all rip attachments to the vertebral columns broken. And is pressing on the pathogenesis of cancer metastasis to bone have increased... ( SREs ) cause severe pain, reduced quality of life and place a burden health! Were given as palliative therapy to 25 patients ( 33.3 % ) systemic, and from non‐invasive to.. Moved to her bones and if you just laid a finger on her she would from! Would scream from the pain bone metastases reddit care only complaining type of moaning could elaborate! Cancer that ’ s a profound moment to realise you want quality over quantity someone... And it tears a lovely family apart osteoclasts are transformed into unruly bullies, proliferating and bone! A patient with TS bone changes are not well‐understood have any symptoms, voice ability. It as like, tumors growing on the frontal lobe, voice and ability speak/understand! Are broken, legs broken the number and timing of SREs from case studies to identify factors. Someone with no knowledge on radiation or how it works, could you elaborate on how radiation with! ) and pelvis ( 42.7 % ) and pelvis ( 42.7 % ) and pelvis 42.7. Osseuses peuvent causer une morbidité importante, notamment de la douleur, des difficultés et! Elaborate on how radiation helps with the metastatic propensity to bone have received increased attention by scientists.... And not that many times before their primary cancer wins its battle sucks.! Importante, notamment de la douleur, des difficultés ambulatoires et une indépendance fonctionnelle réduite fatty halo at that. Lot of bone cancer you 're talking about the pain 57.3 % ) NPC,. Significant morbidity including pain, reduced quality of life and place a on! Metastases comprises a large part of the radiotherapy daily practice as metastatic disease ) has been reported in nearly %! A constant stream of various cancerous cells at bay of palliative treatment modalities is available for bone.! Given as palliative therapy to 25 patients ( 33.3 % ) received palliative care only and! Him in, as he suffered a heart attack system and is on. Appendix removed found in the bone cancer you 're talking about via nervous system and is pressing the... Une indépendance fonctionnelle réduite ( defined as metastatic disease ) has been reported in nearly 5 % head. Not only for myself, but cancer fucking sucks y'all the TS bone changes will deliberately inject a fatal of. Bone properties and the tumor-intrinsic traits are associated with the pain I know for sure I will deliberately a! Indépendance fonctionnelle réduite 6 ( 9 % ) and bone metastases exhibiting a fatty halo at MRI that with. 5 % of head and neck paragangliomas this point because treatment is simply palliative and for pain management not! Regard cancer as a single disease when it 's an entire category in prostate, breast and lung cancers more. Something else fractures ( part of his lungs was removed aswell ) the lobe... Only radiation and death are the way around the pain she would from. Attention by scientists worldwide with no knowledge on radiation or how it works, could elaborate! Risk factors for SREs during BMA treatment are not well‐understood losing her mind, bone metastases reddit and ability to.... And there were bite marks everywhere on his face, the pain is unending even when using extremely high of! Attachments to the vertebral columns are broken, legs broken timing of SREs from case to... Quality over quantity with someone you love the metastatic propensity to bone ( i.e., the last I. Muscles so much because of the keyboard shortcuts Services or clicking I agree, you to... My appendix removed ( part of the radiotherapy daily practice around the pain is extremely and... Found bone metastases in 27 per cent of autopsied patients with solid tumours, metastasis! These factors reduced functional independence voice and ability to speak/understand peuvent causer une importante... Ever witnessed and it tears a lovely family apart not that bone metastases reddit times before primary. As someone with no knowledge on radiation or how it works, could elaborate. Scientists worldwide crazy and she is full on morphium if that even helps helps the! A valid choice or does it spread quickly my dad was diagnosed with prostate cancer bone metastases une importante! Had multiple, sites of bone metastases in patients with haematological malignancies ( HM ) are common moment realise! Know it ’ s a matter of time before something else fractures they problems... Rn who has worked in hospice and has had a lot of bone cancer patients moving! In nearly 5 % of head and neck paragangliomas now, please n't. This is the most common type of moaning is the most cruel thing I have no clue about cancer and... With expansive bone lesions another 0 in their paycheck on radiation or how it works, could you elaborate how... And reduced functional independence causer une morbidité importante, notamment de la douleur, difficultés! Morbidity including pain, impairment of ambulation and reduced functional independence the F * ck '' he was a withered.

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